Addictive Potential: None
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: Unknown
Mechanism of Action: partial agonist for 5-HT(2A) and 5-HT(2C) serotonergic receptors and a1-adrenergic receptors, among others. See more below…
2C-B is also known as 4-bromo-2,5-dimethoxyphenethylamine and Nexus. It is a psychedelic drug of the 2C family, and it is structurally related to DOB. 2C-B was first synthesized by Alexander Shulgin in 1974. It is sold as a white powder sometimes pressed into tablets or gel caps. It is usually taken orally, but it sometimes is insufflated.
2C-B produces dose-dependent psychoactive effects. Threshold effects are noted at approximately 4 mg of an oral dose; the user becomes passive and relaxed and is aware of an integration of sensory perception with emotional states. There is euphoria with increased body awareness and enhanced receptiveness of visual, auditory, olfactory, and tactile sensation. Oral doses of 8 to 10 mg produce stimulant effects and cause a full intoxicated state. Doses in the range of 20 to 40 mg produce LSD-like hallucinations. Onset of subjective effects following 2C-B ingestion is between 20 to 30 minutes with peak effects occurring at 1.5 to 2 hours. Effects of 2C-B can last up to 8 hours.
The graph below (Ray, 2010) shows the affinity of 2C-B for forty-two receptors, arranged in order of decreasing affinity (click the image to enlarge).
As explained by Ray (2010), “The black vertical bar represents a 100-fold drop in affinity relative to the receptor with the highest affinity. As a rule of thumb, this is presumed to be the limit of perceptible receptor interaction. Receptors to the right of the black bar should be imperceptible, while receptors to the left of the black bar should be perceptible, increasingly so the further left they are” (p. 14).
(Info provided by DEA, 2013)
Side Effects and Adverse Reactions:
According to Erowid (2011), some of the negative effects reported by recreational users include:
- nausea and/or vomiting
- tension, muscle twitching
- confusion, difficulty concentrating, problems with activities requiring linear focus
- unpleasant visions
- unwanted and overwhelming feelings
- paranoia, fear, and panic
Individuals who snort 2C-B report extreme pain in their nasal passages and sinuses for up to 30 minutes after ingestion.
- 2C-B: Subjective Effects and Potential Clinical Uses
- 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes
- 2C or not 2C: phenethylamine designer drug review
- More Data About the New Psychoactive Drug 2C-B
- A preliminary investigation of the psychoactive agent 4-bromo-2, 5-dimethoxyphenethylamine: a potential drug of abuse
- Metabolic pathways of 4-bromo-2, 5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human
- Cerebral vasculopathy after 4-bromo-2,5-dimethoxyphenethylamine ingestion