Saturday, March 25, 2017
Breaking News


2ce2C-E is classified as an illegal Schedule I drug in the United States (as of July 2012).

Addictive Potential: Unknown

Emergency Room Visits Yearly: No recorded hospital visits

Mandatory Minimum Sentence: Unknown

Mechanism of Action: inhibits the reuptake of monoamines, which include dopamine, norepinephrine, and serotonin although it exerts its predominant activity upon serotonin and norepinephrine


2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a psychedelic drug and phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin. 2C-E is typically found as a white crystalline powder.

2C-E is commonly active in the 10–25 mg range, taken orally, with effects lasting 8-12 hours.  Insufflating (administering the chemical nasally) requires a much lower dose, typically not exceeding 5 mg, but this method of consumption elicits a noticeably painful or uncomfortable sensation in the nasal cavity for 10 minutes or so.

Many users have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense. Vivid hallucinations similar to those experienced while under the influence of LSD are common.

Side Effects and Adverse Reactions:

2C-E is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally.


The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain

Chapter in Myron J. Stolaroff’s Thanatos To Eros, 35 Years of Psychedelic Exploration discussing author’s experiments with 2C-E

2C-E Entry in PiHKAL

Leave a Reply