Addictive Potential: None
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: Unknown
Mechanism of Action: 5-HT(2A) and 5-HT(2C) receptor agonist
2C-I is a psychedelic drug and phenethylamine of the 2C family. It was developed and popularized by Alexander Shulgin. It was described in Shulgin’s book PIHKAL (Phenethylamines i Have Known And Loved). The drug is sometimes used recreationally but no medical or industrial uses have been reported yet. It is most commonly encountered in the form of its hydrochloride salt (a fluffy, sparkling white powder) and has also been pressed into tablet form.
2C-I is generally taken orally, although it can also be insufflated, or administered rectally (though 2C-I often causes considerable pain upon insufflation). There have also been a few reports of intramuscular and intravenous injections. An oral dose of 2C-I is commonly between 10mg and 25mg, although doses as low as 2mg have been reported to be active. The onset of effects usually occurs within an hour, and the effects of the drug typically last somewhere in the range of 5 to 12 hours.
The effects of 2C-I are often described as quite similar to those of its chemical relative 2C-B, combining psychedelic or hallucinogenic effects typical of drugs such as LSD with the empathogenic or entactogenic effects of drugs such as MDMA. Some users report that the effects are more mental and less sensory than those of 2C-B.
Do not take 2C-I if you are currently taking an MAOI. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Ayahuasca also contains MAOIs (harmine and harmaline). 2C-I and MAOIs are a potentially dangerous combination. Check with your doctor if you are not sure whether your prescription medication is an MAOI (Erowid, 2008).
Side Effects and Adverse Reactions:
Users of 2C-I tend to report a physical stimulant effect, which is often quite strong. Seizures, kidney failure, and fatally high blood pressure have been reported. Deaths have also been reported. However, one website (Erowid, 2012), is of the opinion that the overdoses and deaths were due to 2C-I-NBOMe rather than 2C-I.
There have been no reports of physical dependence or addiction. Comparisons with similar compounds suggest that use of 2C-I is unlikely to result in physical dependence. With that said, 2C-I is a research chemical. This means that virtually no research has been conducted on the toxicity of 2C-I.
Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally, spiritually, or for any other purpose.