Saturday, April 29, 2017
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2ci2C-I (2,5-dimethoxy-4-iodophenethylamine) is classified as an illegal Schedule I drug in the United States (as of July 2012).

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: 5-HT(2A) and 5-HT(2C) receptor agonist


2C-I is also known as 2,5-dimethoxy-4-iodophenethylamine. It is a psychedelic drug and phenethylamine of the 2C family. 2C-I was developed and popularized by Alexander Shulgin. It was described in Shulgin’s book PIHKAL (Phenethylamines i Have Known And Loved). The drug is sometimes used recreationally but no medical uses have been reported. It is most commonly encountered in the form of its hydrochloride salt (a fluffy, sparkling white powder) and has also been pressed into tablet form.

2C-I is generally taken orally, although it can also be insufflated or administered rectally (though 2C-I often causes considerable pain upon insufflation). There have also been a few reports of intramuscular and intravenous injections. An oral dose of 2C-I is commonly between 10mg and 25mg; however, doses as low as 2mg have been reported to be active. The onset of effects usually occurs within an hour, and the effects of 2C-I typically last from 5 to 12 hours.

The effects of 2C-I are often described as quite similar to those of its chemical relative 2C-B, as it is reported to combine the psychedelic effects of drugs like LSD with the empathogenic effects of drugs like MDMA. Still, some users report that the effects are more mental and less sensory than those of 2C-B.

Substance Identification:

              Marquis Reagent       
2C-I dark green to black

(Info provided by DEA, 2013)


2C-I should not be combined with MAOIs. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Ayahuasca also contains MAOIs (harmine and harmaline). 2C-I and MAOIs are a potentially dangerous combination (Erowid, 2008).

Side Effects and Adverse Reactions:

Users of 2C-I tend to report a physical stimulant effect, which is often quite strong. Seizures, kidney failure, and fatally high blood pressure have been reported. Deaths have also been reported. However, one website (Erowid, 2012), is of the opinion that the overdoses and deaths were due to 2C-I-NBOMe rather than 2C-I.

There have been no reports of physical dependence or addiction. Comparisons with similar compounds suggest that use of 2C-I is unlikely to result in physical dependence. With that said, 2C-I is a research chemical. This means that very little research has been conducted on the toxicity of 2C-I.

Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally, spiritually, or for any other purpose.


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