2C-B (4-bromo-2,5-dimethoxyphenethylamine) is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade, or give) without a DEA license. Not available by prescription.
Addictive Potential: None
Emergency Room Visits Yearly: No recorded hospital visits
Mandatory Minimum Sentence: Unknown
Mechanism of Action: partial agonist for 5-HT2 (5-HT2A and 5-HT2C) serotonergic receptors and
a1-adrenergic receptors; At 10-6M, 2C-B also acted as a competitive 5-HT antagonist but at higher
concentrations (2.8x10-5M) acted as a non-competitive 5-HT antagonist
Overview:
2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a psychedelic drug of the 2C family, an entactogen. It was first synthesized by Alexander Shulgin in 1974. In his book PIHKAL (Phenethylamines I Have Known And Loved), the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps. It is usually taken orally, but sometimes is insufflated.
Side Effects and Adverse Reactions:
Because 2C-B is clandestinely produced, users are often unaware of the dose they are ingesting and may be surprised by the drug's effects. Users who ingest relatively low doses of 2C-B and expect MDMA-like effects may actually experience frightening, LSD-like hallucinations. Individuals who snort 2C-B report extreme pain in their nasal passages and sinuses for up to 30 minutes after ingestion. Other side effects include nausea, muscle clenching, anxiety, and claustrophobia. Oral ingestion often results in gastrointestinal distress and increased mucus production that may result in coughing. The September 1998 Journal of Analytical Toxicology reported that very little data exist about the pharmacological properties, metabolism, and toxicity of 2C-B. The relationship between its use and disease and death are unknown (NDIC, 2001).
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