2C-I 2,5-dimethoxy-4-iodophenethylamine

 
2C-I (2ci) 3d

2C-I (2,5-dimethoxy-4-iodophenethylamine) is an Unscheduled Research Chemical, that is not approved for human consumption, in the United States. It is a gray area in the law because it may be illegal and covered under the analog act.

Addictive Potential: None

Emergency Room Visits Yearly: No recorded hospital visits

Mandatory Minimum Sentence: Unknown

Mechanism of Action: 5-HT(2A) and 5-HT(2C) receptor agonist

Overview:

2C-I is a psychedelic drug and phenethylamine of the 2C family. It was developed and popularized by Alexander Shulgin. It was described in Shulgin’s book PIHKAL (Phenethylamines i Have Known And Loved). The drug is used recreationally and as an entheogen but no medical or industrial uses have been reported yet. It is most commonly encountered in the form of its hydrochloride salt (a fluffy, sparkling white powder) and has also been pressed into tablet form.

2C-I is generally taken orally, although it can also be insufflated, or administered rectally as well (though 2C-I often causes considerable pain upon insufflation). There have also been a few reports of intramuscular and intravenous injections. An oral recreational dose of 2C-I is commonly between 10mg and 25mg, although doses as low as 2mg have been reported to be active. The onset of effects usually occurs within an hour, and the effects of the drug typically last somewhere in the range of 5 to 12 hours.

The effects of 2C-I are often described as quite similar to those of its chemical relative 2C-B, combining psychedelic or hallucinogenic effects typical of drugs such as LSD with the empathogenic or entactogenic effects of drugs such as MDMA (ecstasy). Some users report that the effects are more mental and less sensory than those of 2C-B.

 

Warning:

Do not take 2C-I if you are currently taking an MAOI. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Ayahuasca also contains MAOIs (harmine and harmaline). 2C-I and MAOIs are a potentially dangerous combination. Check with your doctor if you are not sure whether your prescription medication is an MAOI (Erowid, 2008).

 

Side Effects and Adverse Reactions:

Users of 2C-I tend to report a physical stimulant effect, which is often quite strong. Although unpleasant physical side effects such as muscle tension, nausea, and vomiting have been reported, their incidence in the use of 2C-I appears to be less common than in the use of some of the other closely related phenethylamines such as 2C-T-2 and 2C-T-7.

Virtually no research has been conducted on the toxicity of 2C-I. No deaths have been attributed to the drug and several large doses (100+ milligrams) have been survived. There have been no reports of physical dependence or addiction. Comparisons with similar compounds suggest that use of 2C-I is unlikely to result in physical dependence. With that said, 2C-I is a research chemical.

Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally.

 

Trip Reports:

2C-I Trip Report

 

Research:

European Union's EMCDDA Scientific Committee's Report on the Risk Assessment of 2C-I in the Framework of the Joint Action on New Synthetic Drugs

DEA Announcement of Online Research Chemical Supplier Arrests (DEA Website)

 

E-books:

The NeuroSoup Trip Guide - The free e-book version of The Neurosoup Trip Guide is now available online. It contains chapters on Choosing the Right Hallucinogen; Set, Setting, and Preparation for a Trip; Tips for Tripsitters; Aspects of the Entheogenic Experience; Working with Difficult Experiences; Integration; and References and Recommended Reading.

 

More Info:

Visit the New Community Trip Reports Area

How to Work With Bad Trips

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