Monday, March 27, 2017
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O-Acetylpsilocin_chemical_s4-AcO-DMT is Unscheduled in the United States. That said, it may possibly be considered an analogue of psilocin, which is a Schedule I drug.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Currently unknown, but likely an agonist of the serotonin receptors


4-AcO-DMT is also known as psilacetin, O-Acetylpsilocin, and 4-acetoxy-N,N-dimethyltryptamine. It is an unscheduled research chemical, and it is thought to be a synthetic prodrug of psilocin. Because of this, it has been suggested to be a potentially useful alternative to psilocybin for pharmacological studies.

4-AcO-DMT is of the tryptamine chemical class, and it is structurally related to DMT, 5-MeO-DMT, bufotenine, psilocybin, and psilocin. Interestingly, 4-AcO-DMT was first discovered and patented by Albert Hofmann and Sandoz Ltd in the early 1960’s (US Patent #3,075,992). Nonetheless, 4-AcO-DMT was not reported as being used recreationally until around 2007.

In the body, 4-AcO-DMT is thought to be rapidly deacetylated to psilocin by acetylases during first pass metabolism. The oral dosage of 4-AcO-DMT is reported to range from 10 mg – 25 mg with effects lasting for 3-10 hours and varying by dosage (Erowid, 2011). Users report that the positive effects are quite similar to those of psilocybin and psilocin with experiences described as euphoric (1), being smooth and intrinsically deep (2), and evoking spiritual wholeness (3).

Trip Reports:

Substance Identification:

     Mecke Reagent  Marquis Reagent     Mandellin Reagent
4-AcO-DMT Dark Blue Light Brown Dark Blue

(Info provided by EcstasyData, 2013)

Side Effects and Adverse Reactions:

According to Erowid (2012) and Erowid (2011), some of the potential negative effects of 4-AcO-DMT include:

  • anxiety and/or fear
  • difficulty speaking
  • motor impairment
  • stomach discomfort, nausea, vomiting, and gas
  • intense or overwhelming visual disturbances
  • overwhelming thoughts and ideas
  • disturbing hallucinations
  • paranoia or insecure feelings
  • sweating, chills, or flushing
  • severe uncomfortable mental and physical stimulation
  • sleeplessness
  • elevated heart rate
  • muscle fatigue, pain, and aching
  • severe mental confusion
  • blackouts at large dosages

Remember, 4-AcO-DMT is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because very little data exists about their side effects, adverse reactions, long term damage, and addiction potential. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are safe to use recreationally.



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