Wednesday, April 26, 2017
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4-methoxyphencyclidine4-MeO-PCP is currently Unscheduled in the United States. Still, it may be considered an analog of PCP, making it illegal via the federal analog act.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: NMDA antagonist and dopamine reuptake inhibitor


4-MeO-PCP is also known as 4-Methoxyphencyclidine and methoxydine. It is a dissociative anesthetic drug with hallucinogenic and sedative effects. It is research chemical that is structurally related to the dissociative drug PCP. Distribution of 4-Meo-PCP among recreational users was first detected by the European Early Warning System in 2011.

(Image by Roth et al. 2013)

Structural similarities of ketamine, methoxetamine, phencyclidine, 4-MeO-PCP, and several other PCP analogues (image by Roth et al. 2013)

Substance Identification:

     Mecke Reagent          Marquis Reagent    
4-MeO-PCP  yellow to green to red  slow red

(Info provided by Morris, 2012)

Side Effects and Adverse Reactions:

4-MeO-PCP is a very new substance, and little is known about its side effects, adverse reactions, long term damage, and/or addiction potential.

Erowid (2012) lists various negative effects reported by recreational users. These effects, which may increase with redosing, include:

  • Disturbing hallucinations and/or delusions
  • Anxiety, paranoia
  • Severe dissociation, depersonalization
  • Ataxia (loss of motor coordination)
  • Psychotic episodes
  • Nausea, vomiting
  • Temporary amnesia
  • Severe distortion or loss of auditory/visual perception

Remember, research chemicals are experimental chemicals that may not be safe for human consumption. This is because not enough data exists currently about their effects in humans. Although some people are willing to ingest research chemicals, it is unreasonable to assume that they are in any way safe to use recreationally.


4-Methoxyphencyclidine: An Analytical Profile

Out with the old, in with the new? Case reports of the clinical features and acute management of two novel designer drugs

‘Legal Highs’-novel and emerging psychoactive drugs: a chemical overview for the toxicologist

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor

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