Saturday, April 29, 2017
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5-APB5-APB is currently Unscheduled in the United States. This is a gray area in the law because it may be illegal under the federal analog act.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: 5ht(2b) full agonist; monoamine reuptake inhibitor of NET, DAT, and SERT


5-APB is also known as 1-(benzofuran-5-yl)propan-2-amine and 5-(2-aminopropyl)benzofuran. It was first synthesized in the 1990s by David Nichols and his team at Purdue University. According to Jebadurai (2013), some of the positive effects reported by recreational users include euphoria, mild visuals, sexual stimulation, and enhanced music appreciation. Because of these effects, some users have even compared its effects to MDMA. Nonetheless, the dosage and duration of 5-APB is different than that of MDMA. Dosages of 5-APB are reported to range from 75 mg – 100 mg, and the duration of effects usually lasts from 9 – 10 hours (Jebadurai).

Substance Identification:

     Mecke Reagent          Marquis Reagent    
5-APB  Black Black

(Info provided by Morris, 2012)

Side Effects and Adverse Reactions:

There is limited empirical data about the side effects, adverse reactions, long term damage, and/or addiction potential of 5-APB. According to Jebadurai (2013), some of the potential negative effects include:

  • Nausea
  • Lethargy
  • Body load
  • Yawning
  • Headaches
  • Dizziness
  • Restless, agitation
  • Unable to stay still
  • Sensitivity to light
  • Terrible hangover the following day

Remember, research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their effects in humans. Although some people are willing to ingest the research chemical 5-APB, it is unreasonable to assume that it is in any way safe to use recreationally.


Neurochemical profiles of some novel psychoactive substances

The Characterization of 5- and 6-(2-Aminopropyl)-2,3-dihydrobenzofuran

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