Thursday, May 25, 2017
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5-IT5-IT is currently Unscheduled in the United States. Still, it may be considered an analog of AMT, making it illegal via the federal analog act.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: MAO inhibitor


5-IT is also known as 5-API or 5-(2-Aminopropyl)indole. It is an indole derivative and a positional isomer of AMT and NMT. Recreational users report that 5-IT produces strong stimulant and amphetamine-like effects. According to Coppola and Mondola (2013), “5-IT is generally consumed intranasally or orally, and the dosage range reported by users is between 50 mg and 120 mg. The onset of action occurs within 30 minutes to 1 hour of ingestion, and the effects may last up to 10 hours”.

Substance Identification:

     Mecke Reagent          Marquis Reagent    
5-IT  brown  dark red

(Info provided by Morris, 2012)

Side Effects and Adverse Reactions:

Very little empirical data exists regarding the side effects, adverse reactions, long term damage, and/or addiction potential of 5-IT.  Coppola and Mondola (2013) list some of the negative effects that have been reported by recreational users. These include:

  • anxiety
  • psychomotor agitation
  • confusion
  • insomnia
  • sweating
  • restlessness
  • tremors
  • jaw clenching
  • dilated pupils
  • increased heart rate
  • increased blood pressure
  • increased body temperature


5-IT was first detected in recreational drug distribution in 2012. Since then, there have been 21 deaths associated with its use (EMCDDA, 2013).


A New Stimulant of Abuse: 5-(2-aminopropyl) indole

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