Wednesday, July 23, 2014
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5-MEO-DIPT

5meodipt5-methoxy-diisopropyltryptamine (5-MEO-DIPT) is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute (sell, trade or give) without a DEA license.

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: agonist at the 5HT receptor, among others (see a more detailed discussion below)

Overview:

5-methoxy-diisopropyltryptamine, also known as 5-methoxy-N,N-diisopropyltryptamine, 5-MeO-DiPT, 5-MeO-DIPT, foxy methoxy, or just foxy, is a tryptamine that is used recreationally as a psychedelic. 5-MeO-DiPT is orally active – dosages between 6–20 mg are commonly reported. Many users note that an unpleasant body load accompanies higher dosages. 5-MeO-DiPT is also taken by insufflation, and sometimes it is smoked or injected.

On April 4, 2003, the United States DEA added both 5-MeO-DiPT and AMT to Schedule I of the Controlled Substances Act under “emergency scheduling” procedures. The drugs were officially placed into Schedule I on September 29, 2004.

Prior to its prohibition in the U.S., 5-MeO-DIPT was sold online alongside psychoactive analogues like DIPT, DPT, and 5-MeO-DMT, none of which have yet been expressly outlawed in that country. However, in July 2004, Operation Web Tryp was concluded, confirming that U.S. Federal law enforcement intends to prosecute sale of these analogs of 5-MeO-DIPT. Previous prosecutions under the Federal Analog Act have met, on occasion, with failure, given some court rulings regarding possible unconstitutional vagueness regarding what substances are properly considered ‘analogs’; such issues may be addressed on appeal.

An average oral dose of 5-MeO-DiPT is between 5-30 mg. According to Erowid.org, “5-MeO-DiPT is often characterized by a strong feeling in the body, sometimes described as buzzing or energy, which some users enjoy and others hate. The effects sought by users include moderate mood lift, euphoria, a sense of well-being, intensification of tactile sensations, visual effects, physcial and mental stimulation, occasional auditory distortions/shifts, and for some users, a significant erotic component. Visual effects may include open and closed eye patterning, movement trails, and brightening or shifting of colors. We have received no reports of completely engrossing visions or hallucinations, or of powerful entheogenic voyages with 5-MeO-DiPT.”

Pharmacology:

The graph below (Ray, 2010) shows the affinity of 5-MEO-DIPT for forty-two receptors, arranged in order of decreasing affinity (click the image to enlarge).

5-MeO-DIPT Receptor Affinity

As explained by Ray (2010), “The black vertical bar represents a 100-fold drop in affinity relative to the receptor with the highest affinity. As a rule of thumb, this is presumed to be the limit of perceptible receptor interaction. Receptors to the right of the black bar should be imperceptible, while receptors to the left of the black bar should be perceptible, increasingly so the further left they are” (p. 14).

Substance Identification:

     Ehrlich’s Reagent          Marquis Reagent    
5-MeO-DIPT HCl purple to blue yellow to black

(Info provided by DEA, 2005)

Side Effects and Adverse Reactions:

5-methoxy-diisopropyltryptamine is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally. Users often report nausea, diarrhea, unsettling and/or anxious stimulation, and muscle tension.

Deaths:

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