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5-MeO-DMT5-MeO-DMT is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute without a DEA license. Not available by prescription.

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Nonselective serotonin (5-HT) agonist


5-MeO-DMT is a psychedelic tryptamine. It is found in a wide variety of plant species and the Bufo Alvarius toad. 5-MeO-DMT was first synthesized in 1936. In 1959, it was isolated as one of the psychoactive ingredients of Anadenanthera peregrine seeds, which are used in Yopo snuff. Like its close relative DMT, it has been used as an entheogen by South American shamans for thousands of years. Interestingly, throughout the 1970s and 1980s, 5-MeO-DMT was also used sacramentally by The Church of the Tree of Life (Erowid, 2011).

The dosage of 5-MeO-DMT is reported to range from 1 mg – 20 mg when smoked, and the effects are reported to last for about 30 minutes (Erowid, 2011). Users have also reported using 5-MeO-DMT sublingually, orally, and by insufflation. 

First person charged for possession of 5-MeO-DMT under the Federal Analog Act in 2009. Please note: This occurred prior to the classification of 5-MeO-DMT as Schedule I in 2011. Therefore5-MeO-DMT was unscheduled and quasi-legal at the time. In 2009-2010, Patrick Malloy was charged with possession of 5-MeO-DMT in the circuit court of the sixteenth judicial circuit in Kane county Illinois (docket- 09CF2059). He was placed on two years felony probation in Kane county with a withheld judgement, although, it shows on his record as a conviction. He served no jail time on the case.

Substance Identification:

     Ehrlich’s Reagent          Marquis Reagent    
5-MeO-DMT purple to blue yellow to black

(Info provided by DEA, 2005)

Side Effects & Adverse Reactions:

According to Erowid (2009), some of the potential negative effects of 5-MeO-DMT include:

  • overly-intense experiences
  • difficulty integrating experiences
  • fear, terror, and panic
  • dysphoria
  • fast onset and intensity can lead to problems if not prepared, like falls, knocking things over, etc.
  • hard on the lungs (when smoked)
  • nasal drip (when insufflated)
  • nausea, vomiting (when insufflated)

Deaths & Overdoses:

Several cases of overdose and death have been associated with the use of 5-MeO-DMT and harmaline. As explained by Shen et al. (2010), “5-MeO-DMT is often co-abused with an MAOI such as harmaline to enhance hallucinations. There are two levels of interactions between harmaline and 5-MeO-DMT, pharmacokinetic and pharmacodynamic. When deamination metabolism is inhibited by harmaline, the systemic and cerebral exposure to 5-MeO-DMT, as well as to the metabolite bufotenine, is sharply elevated and prolonged. Meanwhile, harmaline and 5-MeO-DMT both act agonistically on the serotonergic systems. As a result, coadministration of harmaline potentiates 5-MeO-DMT drug responses and sometimes leads to severe or fatal serotonin toxicity…”


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