Saturday, March 25, 2017
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Bufotenine5-HO-DMT is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute without a DEA license. Not available by prescription.

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Binds and activates the 5-HT2A and 5-HT2C receptors


5-HO-DMT is also known as bufotenine, bufotenin, and 5-hydroxy-N,N-dimethyltryptamine. 5-HO-DMT was first identified in the psychoactive toad Bufo alvarius, which secretes 5-MeO-DMT and bufotenine from its glands. 5-HO-DMT is very similar to the chemical structure of serotonin. As such, it is also sometimes referred to as N,N-dimethylserotonin. Beyond being secreted from Bufo alvarius, 5-HO-DMT is also found in various mushrooms, plants, and mammals.

Ott (2001) reported psychoactive effects of 5-HO-DMT through several routes of administration including intranasal, sublingual, oral, inhaled vapor, and intrarectal. In particular, Ott wrote that he saw “ring-like, swirling, colored patterns with eyes closed; visible, albeit fainter, with eyes opened in low light” after inhaling 8mg of vaporized bufotenine free-base.

Side Effects & Adverse Reactions:

There have been numerous studies of the effects of 5-HO-DMT in humans. Some of the negative effects reported include:

Substance Identification:

             Marquis Reagent     Van Urks Reagent   
5-HO-DMT Green-brown Violet to dark purple

(Info provided by DEA, 2005)


Other Informational Resources:

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