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AET (alpha-ethyltryptamine)

AETAET (Alpha-Ethyltryptamine) is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute without a DEA license. Not available by prescription.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: monoamine oxidase inhibitor; potent monoamine releasing agent; indirect 5-HT agonist


Alpha-Ethyltryptamine is also known as α-ethyltryptamine, etryptamine, α-ET, or AET. It is a psychoactive drug belonging to the tryptamine class. It is structurally related to α-methyltryptamine but its pharmacological effects are very different. AET is not hallucinogenic; rather, its effects are reported to be more empathogenic – like that of MDMA. Dosages of AET are reported to range from 75 mg – 160 mg, and the duration of effects usually lasts from 4 – 6 hours (Erowid, 2011). Shulgin (2009) wrote about AET in TiHKAL; he described the effects of AET as a “very keen, pure euphoria”.

Interestingly, AET was originally explored as an anti-depressant by Upjohn Chemical Company under the name Monase.

“Last week the Upjohn Co. withdrew Monase. a ‘psychic energizer,’ after reporting to FDA that widespread use since June 1961 had produced seven cases of aplastic anemia, four of them fatal—though the drug was tested in 3,500 patients, with no sign of damage to their blood-cell mechanisms, before it was marketed.” – Time Magazine, 1962

In 1993, AET was moved into the U.S. Schedule I list of controlled substances in the United States.

Side Effects and Adverse Reactions:

Some of the potential negative effects include:


Etryptamine, a new designer drug with a fatal effect

Fatal intoxication involving etryptamine


Effects in normal man of alpha-methyltryptamine and alpha-ethyltryptamine

Alpha-ethyltryptamine acetate in the treatment of depression, a study of the methodology of drug evaluation

Neuropharmacological studies on dl-alpha-ethyltryptamine acetate

The effect of D, L-alpha-ethyltryptamine acetate on serotonin metabolism

Alpha-ethyltryptamine acetate in alcoholism: a preliminary report

Characterization of the disruptions of prepulse inhibition and habituation of startle induced by α-ethyltryptamine

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