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Ayahuasca

Psychotria Viridis (One of the Plants in Ayahuasca)

Psychotria Viridis (One of the Plants in Ayahuasca)

The term ayahuasca is sometimes loosely used to mean any combination of an MAOI with DMT. Although, traditionally it is made from the Banisteriopsis caapi vine and other admixtures such as Psychotria viridis.

Although alkaloid content varies across batches and specific recipes, one study reported that an average 100-mL dose of ayahuasca contained 24 mg of DMT, 107 mg of 1,2,3,4-tetrahydroharmine, 20 mg of harmaline, and 170 mg of harmine (Callaway et al., 1996). The beta-carboline MAOI contained in Banisteriopsis caapi range from 0.05% to 1.95% by dry weight and the DMT in Psychotria viridis ranges from 0.1% to 0.66% by dry weight (Rivier & Lindgren, 1972; McKenna et al., 1984).

Upon initial ingestion, effects can begin to be felt between 20 and 60 minutes. The duration of the trip lasts from 2-6 hours of peak effects with 1-8 hours of lingering after-effects, depending on dosage and the individual user.

Dangers:

When ingested orally, MAOIs inhibit the catabolism of dietary amines. Sufficient intestinal MAO-A inhibition can lead to hypertensive crisis, when foods containing tyramine are consumed (so-called “cheese syndrome”), or hyperserotonemia if foods containing tryptophan are consumed. The amount required to cause a reaction exhibits great individual variation and depends on the degree of inhibition, which in turn depends on dosage and selectivity.

The exact mechanism by which tyramine causes a hypertensive reaction is not well understood, but it is assumed that tyramine displaces norepinephrine from the storage vesicles. This may trigger a cascade in which excessive amounts of norepinephrine can lead to a hypertensive crisis. Another theory suggests that proliferation and accumulation of catecholamines causes hypertensive crises.

Frequency of Bad Trips.  Cole (2014) examined the estimated frequency of bad trips associated with the use of oral DMT with an MAOI through an online survey of recreational users (n=391); 5.4% of respondents reported experiencing bad trips during all of their oral DMT/MAOI experiences, while 68.5% of respondents reported never having bad trips on oral DMT with an MAOI.

MAOI Sources

Traditional:

Ayahuasca Analogs:

Pharmahuasca:

    • Moclobemide (MAOI-A)

DMT Sources

Traditional:

Ayahuasca Analogs:

Pharmahuasca:

Videos:

Research:

Recommended In-Print Books:

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