Addictive Potential: Unknown
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: Unknown
Mechanism of Action: Cannabinoid receptor agonist
JWH-250 (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11nM at CB1 and 33nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2′-methoxyphenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands.
JWH-250 was discovered by and named after Dr. John W. Huffman. Samples of JWH-250 were first identified in May 2009 by the German Federal Criminal Police, as an ingredient in new generation “herbal smoking blends” which had been released since the banning of the original ingredients CP 47,497 and JWH-018.
The average dose is around 4-10mg smoked and the effects usually last for 0.5-1.5 hours.
Side Effects and Adverse Reactions:
JWH-250 is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally.
JWH-250 and Drug Tests:
JWH-250 is a synthetic cannabinoid that currently cannot be detected with drug tests. This is because of how drug tests work. The basic concept is that your body attempts to break down any drugs you ingest. Metabolites are formed as part of this process; testing looks for the specific types of metabolites that could only occur as a result of drug taking. There is currently (as of Nov, 2009) no test that tests for the metabolites of synthetic cannabinoids. Rumor has it that scientists are developing a drug test that tests for them, although, the development and implementation process could take years.