Addictive Potential: Unknown
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: Unknown
Mechanism of Action: Cannabinoid receptor agonist
WIN 55212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 3.3 and 62.3 nM for human recombinant CB1 and CB2 receptors, respectively. WIN 55212-2 is a full agonist at the CB1 receptor and has higher affinity than THC for the CB1 receptor. It has been found to be a potent analgesic in a rat model of neuropathic pain. It activates p42 and p44 MAP kinase via receptor-mediated signaling.
WIN 55,212-2 is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer’s Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflamatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.
Side Effects and Adverse Reactions:
WIN 55,212-2 is a research chemical. Research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their side effects, adverse reactions, long term damage, addiction potential, etc. Although some people are willing to ingest research chemicals, it is not reasonable to assume that they are in any way safe to use recreationally.
WIN 55,212-2 and Drug Tests:
WIN 55,212-2 is a synthetic cannabinoid that currently cannot be detected with drug tests. This is because of how drug tests work. The basic concept is that your body attempts to break down any drugs you ingest. Metabolites are formed as part of this process; testing looks for the specific types of metabolites that could only occur as a result of drug taking. There is currently (as of Nov, 2009) no test that tests for the metabolites of synthetic cannabinoids. Rumor has it that scientists are developing a drug test that tests for them, although, the development and implementation process could take years.