Psychotria viridis is Uncontrolled in the United States, however, it is not approved for human consumption. This is a gray area of the law because the seeds contain, DMT, which is a Schedule I.
Addictive Potential: None
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: None
Mechanism of Action: Increases Serotonin when combined with an MAOI
Psychotria viridis is one of the traditional admixtures used to make ayahuasca. It is traditionally combined with Banisteriopsis caapi. The leaves of Psychotria viridis contain DMT; according to McKenna (1984), the concentration is between 0.10% to 0.66%.
Psychotria viridis is currently legal to buy, sell, and possess in the United States.
General MAOI warnings. When ingested orally, MAOIs inhibit the catabolism of dietary amines. Sufficient intestinal MAO-A inhibition can lead to hypertensive crisis, when foods containing tyramine are consumed (so-called “cheese syndrome”), or hyperserotonemia if foods containing tryptophan are consumed. The amount required to cause a reaction exhibits great individual variation and depends on the degree of inhibition, which in turn depends on dosage and selectivity.
The exact mechanism by which tyramine causes a hypertensive reaction is not well understood, but it is assumed that tyramine displaces norepinephrine from the storage vesicles. This may trigger a cascade in which excessive amounts of norepinephrine can lead to a hypertensive crisis. Another theory suggests that proliferation and accumulation of catecholamines causes hypertensive crises.
- Pharmacokinetics of Hoasca alkaloids in healthy humans
- Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics
- Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively
- Hallucinogens and dissociative agents naturally growing in the United States
- “Ayahuasca,” the South American hallucinogenic drink: An ethnobotanical and chemical investigation
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