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DOB is Schedule I in the United States. This means it is illegal to manufacture, possess, or distribute without a DEA license. Not available by prescription.

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Selective serotonin 5-HT2A,2C receptor agonist


DOB is also known as 2,5-dimethoxy-4-bromoamphetamine, Brolamfetamine, and Bromo-DMA. It is a psychedelic phenethylamine described by Alexander Shulgin in PiHKAL. Shulgin (2009) reported the dosage of DOB ranging from 1-3 mg and the duration lasting for 8-30 hours. Although Erowid (2011) reported the positive effects to include “heart-opening happiness”,  increased energy, and light visuals, there are also a whole host of possible negative effects (see the list below).

Throughout the last few decades, DOB has been misrepresented as LSD within illicit drug distribution channels. According to Dancesafe (2014), “Upon tasting the chemical, if one notices a highly bitter or “chemically” taste, this should serve as a warning sign that the drug is not LSD, but likely a psychedelic amphetamine (DOB, DOC, DOI, DOM.)”. Misrepresenting DOB as LSD could pose serious health consequences for recreational users as the dosages, effects, and adverse reactions differ.

It also must be mentioned that alcohol may potentiate the effects of DOB (Delliou, 1983).

Substance Identification:

              Marquis Reagent     Simons Reagent  
DOB bright yellow/green  no reaction

(Info provided by Erowid, 2003; dmt-nexus, 2011)

Side Effects and Adverse Reactions:

DOB Blotter

DOB Blotter

Various negative effects of DOB have been reported by users. According to Erowid (2011), these include:

  • nervousness
  • muscle and jaw tension
  • tension headache
  • eye discomfort
  • achy back spasms
  • nausea
  • general body discomfort

It must be emphasized that, if high doses are consumed, DOB can be very damaging. Some of the negative effects of high doses include:

Deaths and Overdoses:

Nonfatal and fatal DOB (2, 5-dimethoxy-4-bromamphetamine) overdose

Diffuse vascular spasm associated with 4-bromo-2, 5-dimethoxyamphetamine ingestion


4-Bromo-2, 5-dimethoxyamphetamine: psychoactivity, toxic effects and analytical methods

Chemical identification of 2, 5-dimethoxy-4-bromoamphetamine (DOB)

LSD and DOB: interaction with 5‐HT2A receptors to inhibit NMDA receptor‐mediated transmission in the rat prefrontal cortex

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