Saturday, April 29, 2017
Breaking News


2,5-Dimethoxy-4-chloroamphetamineDOC is currently Unscheduled in the United States. It is a gray area in the law because it may be illegal under the Federal Analog Act.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Binds to 5HT(2a), 5HT(2b), and 5HT(2c) receptors


DOC is also referred to as 2,5-Dimethoxy-4-chloroamphetamine. It is a psychedelic phenethylamine that is closely related to DOB. In 2006, the DEA reported the first seizure of DOC on blotter paper being distributed as LSD in Florida. They wrote that, “although typical of LSD blotter acid in appearance, the paper did not fluoresce under UV, and methanolic extracts spotted on filter paper did not give the characteristic purple color when treated with Ehrlich’s reagent (PDAB).” After this, DOC was also found being misrepresented as LSD on blotter paper in Kansas, Georgia, Florida, Pennsylvania, and California during the years 2007-2009 and as liquid in New Mexico, Florida, and Michigan from 2006-2007 (Kerrigan, 2013). It is safe to assume that DOC is still being misrepresented as LSD in illicit drug distribution to this day.

Misrepresenting DOC as LSD is a serious health concern for recreational users because the dosages, side effects, and adverse reactions of the two substances are markedly different. Jebadurai (2013) emphasized that “DOC is considered to possess severe toxicological effects in high doses. Compared with LSD, DOC does not have a confirmed safety profile.”

In PiHKAL, Shulgin (2009) reported that the dosage of DOC ranges from 1.5 mg to 3.0 mg, and the duration of effects last for 12 to 24 hours. Furthermore, Shulgin called DOC an “archetypical psychedelic”. He wrote, “Everything is there in spades, with few if any of the subtle graces, the `gentle images’ and `gentle fantasies’ of the 2-carbon phenethylamines. This is the works. There are visuals, and there are interpretive problems with knowing just where you really are. The place where nothing makes sense, and yet everything makes sense. I have just slept for a few hours, and now I am awake and it has been eighteen hours, and there is a lot still going on, although I have a relaxed, good feeling. Anyone who uses this had better have 24 hours at their disposal.”

Substance Identification:

               Marquis Reagent   
DOC  Dark Green

(Info provided by DMT-Nexus, 2011)

Side Effects & Adverse Reactions:

There is limited empirical data about the side effects, adverse reactions, long term damage, and/or addiction potential of DOC. According to Jebadurai (2013), some of the potential negative effects include:

  • Sympathomimetic effects (palpitation)
  • Tiredness due to the length of the experience
  • Paranoid delusions
  • Drug induced psychosis
  • Intense anxiety and produced mental ‘trauma’
  • Poor concentration

Remember, research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their effects in humans. Although some people are willing to ingest the drug DOC, it is unreasonable to assume that it is in any way safe to use recreationally.

Deaths and Overdoses:


More Informational Resources:

Leave a Reply