Addictive Potential: None
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: Unknown
Mechanism of Action: 5HT(2) and 5HT (1c) partial agonist
DOM is also referred to as STP and 2,5-dimethoxy-4-methylamphetamine. It is a psychedelic phenethylamine that is typically used orally. Erowid (2011) reported that the dosage of DOM ranges from 0.5 mg to 12 mg, and Shulgin (2004) reported that the effects usually last for 14 to 20 hours. A clinical study of DOM in humans “indicated that low doses of DOM produced significantly increased feelings of anxiety, euphoria, dysphoria, with somatic and LSD-like symptoms when compared to the control group” (Faillace et al., 1970).
According to NIDA (1973), “the LD50 of DOM (the dose required to produce death in 50% of the population to which a drug is administered) in rats is 60 mg/kg. Although numerous instances of ‘freak-outs’ have been attributed to STP (DOM), no human deaths resulting from a lethal dose of the drug have been reported.”
DOM was first synthesized and tested in 1963 by Alexander Shulgin. By mid-1967, tablets containing 20 mg (later 10 mg) of DOM were being widely distributed in the Haight-Ashbury District of San Francisco under the name STP. This short-lived appearance of DOM on the black market proved disastrous for several reasons. First, the tablets contained an excessively high dose of the chemical. This, combined with DOM’s slow onset of action (which encouraged some users, familiar with drugs that have quicker onsets, such as LSD, to re-dose) and its remarkably long duration, caused many users to panic and sent some to the emergency room. Second, treatment of such overdoses was complicated by the fact that no one at the time knew that the tablets called STP were, in fact, DOM.
|Mecke Reagent||Froede Reagent||PDMB Reagent|
|2,5-dimethoxy-4-methylamphetamine hcl||Deep olive green to deep blue||Deep dark blue||Brilliant yellow to deep yellow|
(Info provided by UNODC, 2009)
Side Effects & Adverse Reactions:
Some of the potential negative effects of DOM include:
- unpleasant hallucinations
- intense anxiety and/or panic
For more information on the effects of DOM, read this review of the research by NIDA (1973).
- Lysergic acid diethylamide and 2, 5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis
- 2, 5-Dimethoxy-4-methylamphetamine: Clinical evaluation of a new hallucinogenic drug
- 2, 5-Dimethoxy-4-methylamphetamine (DOM), a neuropharmacological examination
- The psychotomimetic amphetamines with special reference to DOM (STP) toxicity