Mushroom Drug Is Studied Anew
Wall Street Journal Article By RON WINSLOW
July 11, 2006; Page B1
In a study that could revive interest in researching the effects of psychedelic drugs, scientists said a substance in certain mushrooms induced powerful, mind-altering experiences among a group of well-educated, middle-age men and women.Johns Hopkins Medical Institutions researchers conducted the study following carefully controlled, scientifically rigorous procedures. They said that the episodes generally led to positive changes in attitude and behavior among the 36 volunteer participants and that the changes appeared to last at least two months. Participants cited feelings of intense joy, "distance from ordinary reality," and feelings of peace and harmony after taking the drug. Two-thirds described the effects of the drug, called psilocybin, as among the five most meaningful experiences of their lives.
But in 30% of the cases, the drug provoked harrowing experiences dominated by fear and paranoia. Two participants likened the episodes to being in a war. While these episodes were managed by trained monitors at the sessions where the drugs were taken, researchers cautioned that in less-controlled settings, such responses could trigger panic or other reactions that might put people in danger.
A report on the study, among the first to systematically assess the effects of hallucinogenic substances in 40 years, is being published online today by the journal Psychopharmacology. An accompanying editorial and commentaries from three prominent neuroscientists and a psychiatrist praise the study and argue that further research into such agents has the potential to unlock secrets of consciousness and lead to new therapeutic strategies for depression, addiction and other ailments.
In one of the commentaries, Charles R. Schuster, a neuroscientist and former head of the National Institute for Drug Abuse, called the report a "landmark paper." He also expressed hope that it "renews interest in a fascinating and potentially useful class of psychotropic agents."
Still, the research is likely to stir controversy. Though psilocybin mushrooms, which can be found growing wild throughout the world, have been used for centuries in some societies during spiritual rituals, they also were agents, along with such hallucinogens as LSD and mescaline, that fueled the "Turn On, Tune In, Drop Out" counterculture of the 1960s personified by Timothy Leary.
Researchers acknowledge that the study's positive findings may encourage inappropriate use of the agents. Roland Griffiths, the Hopkins neuroscientist who headed the research, warned against viewing the results as a green light for consuming the mushrooms. "We don't know all their dark sides," he said. "I wouldn't in any way want to underestimate the potential risks" of indiscriminate use of the drugs.
The National Institute for Drug Abuse, which co-sponsored the study as part of its support for research into drugs of abuse, also warned against eating psilocybin mushrooms. They "act on serotonin receptors in the brain to profoundly distort a person's perception of reality," the institute said, possibly triggering psychosis, paranoia and anxiety.
It was widespread abuse in the 1960s that led to hallucinogens becoming illegal, effectively shutting down then-burgeoning corporate and academic research programs that had suggested the agents might be valuable research and therapeutic tools. One of the last influential studies was the Good Friday Experiment in 1962 in which 20 seminary students were given either psilocybin or nicotinic acid during a religious service. The 10 who got psilocybin reported intense spiritual experiences with positive benefits; one follow-up study suggested those effects lasted 25 years.
"It's remarkable that we have a class of compounds that has sat in the deep freeze for 40 years," Dr. Griffiths said. "It seemed to me scientifically it was high time to look again" at psychedelic agents.
Known colloquially by such names as magic mushroom or sacred mushroom, psilocybin is considered a Schedule I substance under the U.S. Controlled Substances Act. That puts it in the same class as heroin and LSD, drugs that have a high potential for abuse and no known medical use. It isn't considered addictive. The psilocybin used in the study was synthesized by David E. Nichols, a professor of medicinal chemistry at Purdue University, West Lafayette, Ind., under a special permit.
After getting approval from the Drug Enforcement Administration, the Food and Drug Administration and an institutional review board at Hopkins, Dr. Griffiths and his colleagues circulated a flier seeking volunteers for a "study of states of consciousness brought about by a naturally occurring psychoactive substance used sacramentally in some cultures."
From among the 135 people who responded, 36 were eventually selected, based in part on their lack of a history of psychedelic drug use or family history of serious psychiatric disorders such as schizophrenia. The 36 -- 14 men and 22 women -- ranged in age from 24 to 64 years old, with an average age of 46; 97% were college graduates, and 56% had post-graduate degrees. All 36 participated at least occasionally in religious or spiritual activities. (Dr. Griffiths declined to make any participants available for interviews, citing privacy issues.)
Thirty of the participants were randomly assigned to receive either psilocybin or Ritalin (known generically as methylphenidate) as a control for the first eight-hour session; two months later, they were given the other drug in another session. Neither the participants nor the monitors who were present during their sessions knew which agent was being taken. To further reduce chances that participant responses would be affected by expectations they were getting psilocybin, a third group of six participants was randomly assigned to receive Ritalin in both sessions, followed by a third session when they knew they were getting the psychedelic agent. Ritalin was selected as the control agent in part because it can cause mood-changing effects similar to those of psilocybin, researchers said. It also takes effect at about the same time and lasts for about as long.
Participants were given the drug in individual sessions in a living-room environment with two experienced monitors. They were blindfolded, given headphones to listen to classical music and encouraged to lie down and direct their thoughts inward.
Researchers provided participants with a battery of questionnaires and mysticism scales, some of which were developed based on research from more than four decades ago, to measure their impressions of their experience at the end of the session and again two months later.
A third of the participants said the experience with psilocybin was the single most significant experience of their lives, and an additional 38% rated it among their top five such experiences -- akin to, say, the birth of a first child or the death of a parent. Just 8% of the Ritalin episodes were reported to be among the top five meaningful occurrences. Two months after the sessions, 79% of the participants indicated in questionnaires that their sense of well-being and satisfaction increased after the psilocybin episodes, compared with 21% for Ritalin.
Researchers hope the findings will spur other studies that will, for instance, compare the effects of other hallucinogens and use MRIs to observe how such drugs affect the human brain. Other efforts are expected to test the value of psilocybin as a therapy. Charles Grob, a researcher at UCLA, is heading a small study to see if the drug relieves anxiety, depression and pain among patients with advanced cancer.
Dr. Griffiths said another goal is to understand the consequences of spiritual experiences -- both drug-induced and spontaneous -- and to determine how long they last and whether they lead to personality changes.
Mushroom Drug Produces Mystical ExperienceBy The New York Times
July 11, 2006NEW YORK (AP) -- People who took an illegal drug made from mushrooms reported profound mystical experiences that led to behavior changes lasting for weeks -- all part of an experiment that recalls the psychedelic '60s.
Many of the 36 volunteers rated their reaction to a single dose of the drug, called psilocybin, as one of the most meaningful or spiritually significant experiences of their lives. Some compared it to the birth of a child or the death of a parent.
Such comments ''just seemed unbelievable,'' said Roland Griffiths of the Johns Hopkins University School of Medicine in Baltimore, the study's lead author.
But don't try this at home, he warned. ''Absolutely don't.''
Almost a third of the research participants found the drug experience frightening even in the very controlled setting. That suggests people experimenting with the illicit drug on their own could be harmed, Griffiths said.
Viewed by some as a landmark, the study is one of the few rigorous looks in the past 40 years at a hallucinogen's effects. The researchers suggest the drug someday may help drug addicts kick their habit or aid terminally ill patients struggling with anxiety and depression.
It may also provide a way to study what happens in the brain during intense spiritual experiences, the scientists said.
Funded in part by the federal government, the research was published online Tuesday by the journal Psychopharmacology.
Psilocybin has been used for centuries in religious practices, and its ability to produce a mystical experience is no surprise. But the new work demonstrates it more clearly than before, Griffiths said.
Even two months after taking the drug, pronounced SILL-oh-SY-bin, most of the volunteers said the experience had changed them in beneficial ways, such as making them more compassionate, loving, optimistic and patient. Family members and friends said they noticed a difference, too.
Charles Schuster, a professor of psychiatry and behavioral neuroscience at Wayne State University and a former director of the National Institute on Drug Abuse, called the work a landmark.
''I believe this is one of the most rigorously well-controlled studies ever done'' to evaluate psilocybin or similar substances for their potential to increase self-awareness and a sense of spirituality, he said. He did not participate in the research.
Psilocybin, like LSD or mescaline, is one of a class of drugs called hallucinogens or psychedelics. While they have been studied by scientists in the past, research was largely shut down after widespread recreational abuse of the drugs during the 1960s, Griffiths said. Some work resumed in the 1990s.
''We've lost 40 years of (potential) research experience with this whole class of compounds,'' he said. Now, with modern-day scientific methods, ''I think it's time to pick up this research field.''
The study volunteers had an average age of 46, had never used hallucinogens, and participated to some degree in religious or spiritual activities like prayer, meditation, discussion groups or religious services. Each tried psilocybin during one visit to the lab and the stimulant methylphenidate (better known as Ritalin) on one or two other visits. Only six of the volunteers knew when they were getting psilocybin.
Each visit lasted eight hours. The volunteers lay on a couch in a living-room-like setting, wearing an eye mask and listening to classical music. They were encouraged to focus their attention inward.
Psilocybin's effects lasted for up to six hours, Griffiths said. Twenty-two of the 36 volunteers reported having a ''complete'' mystical experience, compared to four of those getting methylphenidate.
That experience included such things as a sense of pure awareness and a merging with ultimate reality, a transcendence of time and space, a feeling of sacredness or awe, and deeply felt positive mood like joy, peace and love. People say ''they can't possibly put it into words,'' Griffiths said.
Two months later, 24 of the participants filled out a questionnaire. Two-thirds called their reaction to psilocybin one of the five top most meaningful experiences of their lives. On another measure, one-third called it the most spiritually significant experience of their lives, with another 40 percent ranking it in the top five.
About 80 percent said that because of the psilocybin experience, they still had a sense of well-being or life satisfaction that was raised either ''moderately'' or ''very much.''
