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EscalineEscaline is currently unscheduled in the United States. However, this is a gray area of the law, which means it may be illegal via the federal analog act.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: 5-HT agonist


Escaline is also known as 3,5-dimethoxy-4-ethoxyphenethylamine. It is a psychedelic drug and mescaline analog of the phenethylamine class. Shulgin (1995) reported that the oral dosage of escaline ranged from 40mg – 60mg with the duration of effects typically lasting for 8 to 12 hours. Shulgin described the effects of a 60mg oral dose as follows: “there is a quality of rational analysis and insight that is totally impressive. Many subtle factors in my life can be viewed with insight, and usefully dissected. I got into a deep discussion, but I was not argumentative or even defensive and I remained detached and kept a tone of cool impersonality. I had a good appetite. But I also had some tachycardia and muscular tension. There was unquestionable sensory enhancement, but without an intellectual component. Overall it was most pleasant.”

Escaline vs. mescaline. According to Shulgin (1978), escaline “differs from mescaline in that the onset of action is quicker (within the first hour) and there is no nausea noted, but otherwise the time course, and much of the qualitative content, is quite similar.”

Substance Identification:

       Marquis Reagent  
Escaline Orange

(Info provided by DHPForum & Bluelight)

Side Effects and Adverse Reactions:

There is currently limited empirical data available on the side effects, adverse reactions, long term damage, and/or addiction potential of escaline. Several side effects reported by Shulgin (1995) include:

  • body tension
  • tachycardia
  • incoordination

Remember, research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their effects in humans. Although some people are willing to ingest escaline, it is unreasonable to assume that it is in any way safe to use recreationally.


Other Informational Resources:

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