Saturday, March 25, 2017
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Gabapentin (Neurontin)

Neurontin is available by prescription in the United States.

Addictive Potential: Low

Emergency Room Visits Yearly: Unknown

Mandatory Minumum Sentence: Not Scheduled, Does Not Apply; Legal by Prescription

Mechanism of Action: Increases the Neurotransmitter GABA

Overview:

Gabapentin (brand name: Neurontin®) was initially synthesized to mimic the structure of GABA for the treatment of epilepsy. Nowadays, gabapentin has been widely used as a medication to relieve pain, especially neuropathic pain.

Gabapentin is similar in structure to the neurotransmitter GABA but is not believed to act on the same brain receptors. Its exact mechanism of action is unknown, but its therapeutic action on neuropathic pain is thought to involve voltage-gated N-type calcium ion channels. It is thought to bind to the α2δ subunit of the voltage-dependent calcium channel in the central nervous system.

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