Thursday, May 25, 2017
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ketamine_2d_3dKetamine is Schedule III in the United States. This means it is illegal to sell without a DEA license and illegal to buy or possess without a license or prescription.

Addictive Potential: Low

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Not more than 5 years

Mechanism of Action: NMDA receptor antagonist


Ketamine is a dissociative anesthetic for human and veterinary use. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar, or on the street as Special K. Pharmacologically, ketamine is classified as an NMDA receptor antagonist, and like other drugs of this class such as tiletamine, memantine, and phencyclidine (PCP), induces a state referred to as “dissociative anesthesia.” As with other pharmaceuticals of this type, ketamine is used illicitly as a recreational drug.

Ketamine has a wide range of effects in humans, including analgesia, anesthesia, hallucinations, arterial hypertension, and bronchodilation. It is primarily used for the induction and maintenance of general anesthesia, usually in combination with some sedative drug. Other uses include sedation in intensive care, analgesia (particularly in emergency medicine), and treatment of bronchospasm. It is also a popular anesthetic in veterinary medicine.

Ketamine was first reported in 1962 as part of an effort to find a safer anaesthetic alternative to Phencyclidine (PCP), which was more likely to cause hallucinations and seizures. The drug was first given to American soldiers during the Vietnam War, but today in the developed world its use on humans has been dramatically curtailed because of concern about its potential to cause emergence phenomena because of the drug’s possible psychotomimetic effects. However, it is still used widely in veterinary medicine, or as a battlefield anaesthetic in developing nations.

Ketamine’s side effects eventually made it a popular psychedelic in 1965. The drug was used in psychiatric and other academic research through the 1970s, culminating in 1978 with the publishing of John Lilly’s The Scientist, a book documenting the author’s ketamine, LSD, and isolation tank experiments. The incidence of recreational ketamine use increased through the end of the century, especially in the context of raves and other parties. The increase in illicit use prompted ketamine’s placement in Schedule III of the United States Controlled Substance Act in August 1999.


Psychological: Decreased awareness of general environment, sedation, dream-like state, vivid dreams, feelings of invulnerability, increased distractibility, disorientation, and subjects are generally uncommunicative. Intense hallucinations, impaired thought processes, out-of-body experiences, and changes in perception about body, surroundings, time and sounds. Delirium and hallucinations can be experienced after awakening from anesthesia (NHTSA, 2013).

Physiological: Anesthesia, cataplexy, immobility, tachycardia, increased blood pressure, nystagmus, hypersalivation, increased urinary output, profound insensitivity to pain, amnesia, slurred speech, and lack of coordination (NHTSA, 2013).

Performance: Broad spectrum of cognitive impairments and marked dissociative effects. Increased distractibility and intensely visual or polysensual hallucinations. Impairment of immediate and delayed recall, and verbal declarative memory. Memory impairment is associated with encoding or retrieval processes, and not accounted for by decreased attention. Impaired language function, failure to form and use memory traces of task relevant information. Overall decreased awareness, increased reaction time, distorted perceptions of space, non-responsiveness, and blurred vision. The S-(+) isomer impairs psychomotor function 3-5 times more than the R-(-) isomer (NHTSA, 2013).

Substance Identification:

     Mandelin Reagent             
Ketamine  Red Orange

(Info provided by EZTest, 2013)

Side Effects and Adverse Reactions:

According to (NHTSA, 2013), some of the negative effects of ketamine include:

  • anxiety
  • chest pain
  • palpitations
  • agitation
  • rhabdomyolysis
  • flashbacks
  • delirium
  • dystonia
  • psychosis
  • schizophenic-like symptoms
  • dizziness
  • vomiting
  • seizures
  • paranoia


General Ketamine Information

Krystle Talks with James About Cocaine, Ketamine, & Meditation

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