Saturday, March 25, 2017
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lsa_2d_molecule_picLSA (d-lysergic acid amide) is Schedule III in the United States.

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: None

Mechanism of Action: Partial agonist of the serotonin receptors


LSA, also known as d-lysergic acid amide, d-lysergamide, ergine, and LA-111, is an alkaloid of the ergoline family that occurs in various species of vines of the Convolvulaceae and some species of fungi like Ergot and Acremonium (Sleepy Grass). It is the dominant alkaloid in the entheogenic seeds of Rivea corymbosa (Ololiuhqui) and Ipomoea violacea (Morning Glory), and Argyreia nervosa (Hawaiian baby woodrose).

LSA is a precursor to LSD. Although, it is debated as to whether it really has similar effects to LSD. According to Alexander Shulgin in TIHKAL, “This is an active compound and has been established as a major component in morning glory seeds. It was assayed for human activity, by Albert Hofmann in self-trials back in 1947, well before this was known to be a natural compound. An i.m. administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours. Other observers have confirmed this clouding of consciousness leading to sleep. The epimer, inverted at C-8, is isoergine or d-isolysergamide, and is also a component of morning glory seeds. Hofmann tried a 2 milligram dose of this amide, and as with ergine, he experienced nothing but tiredness, apathy, and a feeling of emptiness. Both compounds are probably correctly dismissed as not being a contributor to the action of these seeds. It is important to note that ergine, as well as lysergic acid itself, is listed as a Schedule III drug in the Controlled Substances Act, as a depressant. This is, in all probability, a stratagem to control them as logical precursors to LSD.”


Mixing the Kykeon – by Peter Webster, Daniel M. Perrine, Carl A. P. Ruck

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