Thursday, April 24, 2014
Breaking News

LSZ

LSD-azetidineLSZ is currently Unscheduled in the United States. It is a gray area in the law because it may be covered under the analog act.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: agonist of the 5HT2A receptor

Overview:

LSZ is also known as Lysergic acid 2,4-dimethylazetidide, and LA-SS-Az. It is an analog of LSD developed by a team led by David E. Nichols at Purdue University. LSZ was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor.

It is quite possible that LSZ was distributed in 2000-2003 as “diazadine“. Although the recreational use of LSZ did not truly begin until 2013; multiple users have uploaded their trip reports online to popular sites like Erowid.

Side Effects & Adverse Reactions:

LSZ is a very new substance, and little is known about its side effects, adverse reactions, long term damage, and/or addiction potential. Remember, research chemicals are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their effects in humans. Although some people are willing to ingest research chemicals, it is unreasonable to assume that they are safe to use recreationally.

Research:

Lysergamides of Isomeric 2,4-Dimethylazetidines Map the Binding Orientation of the Diethylamide Moiety in the Potent Hallucinogenic Agent N,N-Diethyllysergamide (LSD)

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