Overview:
Mesembrine is an alkaloid present in Sceletium tortuosum (Kanna). One patent claims that mesembrine is a serotonin reuptake inhibitor. It has also been shown to be a PDE4 inhibitor.
Sceletium tortuosum contains about 1-1.5% total alkaloids. There is about 0.3% mesembrine in the leaves and 0.86% in the stems of the plant.
Side Effects and Adverse Reactions:
As it is currently understood, Mesembrine will most likely not produce any major side effects. Some individuals will experience drowsiness, thus it must not be taken before operating any type of machinery or. Also, it should not be taken in conjunction with any other psychoactive substance or by pregnant or nursing women, except under the supervision of your health professional.
More research is needed to understand the full spectrum of side effects, adverse reactions, and addiction potential.
Research:
Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review
The Distribution of Mesembrine Alkaloids in Selected Taxa of Kanna and their Modification in the Sceletium Derived `Kougoed'
Pharmaceutical compositions containing mesembrine and related compounds
E-books:
The NeuroSoup Trip Guide - The free e-book version of The Neurosoup Trip Guide is now available online. It contains chapters on Choosing the Right Hallucinogen; Set, Setting, and Preparation for a Trip; Tips for Tripsitters; Aspects of the Entheogenic Experience; Working with Difficult Experiences; Integration; and References and Recommended Reading.
More Info:
Visit the New Community Trip Reports Area
How to Work With Bad Trips
Buy Legal Entheogens
