Methoxetamine (MXE) is currently Unscheduled in the United States. Although several states have classified it as an illegal Schedule I drug including Indiana, Florida, Minnesota, North Dakota, Virginia, and Ohio.
Addictive Potential: Unknown
Emergency Room Visits Yearly: Unknown
Mandatory Minimum Sentence: NA
Mechanism of Action: antagonist at the NMDA receptor
Methoxetamine is also referred to as MXE, Mexxy, Roflcopter, 3-Me-O-2-Oxo-PCE, and (2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone). MXE is a newly developed synthetic drug/research chemical. The EMCDDA, which monitors the European Union for new psychoactive substances, first identified methoxetamine being distributed recreationally in November of 2010. By July of 2011, the EMCDDA had identified 58 websites selling the drug.
Methoxetamine is an analog of ketamine, and it produces similar effects. As Corazza et al. (2013) explained, “MXE presents with the same dissociative effect of KET [ketamine], but with slower onset and longer duration of action. However, MXE seems to be associated with worse side effects than KET, ranging from mood disturbances/suicidal attempts to acute cerebellar toxicity. After 50 years of its discovery, KET has led to the emergence of MXE. However, this latter derivative does not appear to be a safer alternative to KET itself.” That said, some researchers still believe that methoxetamine could be useful in treating patients with depression (Coppola et al., 2012).
According to Rosenbaum et al. (2012), “Methoxetamine can be ingested orally, inserted rectally, insufflated, or injected intramuscularly. Typical doses range from 10 to 15 mg, with users reporting effects beginning in 10 min that last 1 to 2 h. Compulsive re-dosing has been described.”
Side Effects & Adverse Reactions:
MXE is a relatively new substance, and little is known about its long term health effects and/or addiction potential. Still, some of the negative effects reported include:
- severe dissociation (ACMD, 2012)
- cardiovascular effects including tachycardia and hypertension (ACMD, 2012)
- paranoid thoughts (ACMD, 2012; Rosenbaum et al., 2012)
- unpleasant hallucinations (ACMD, 2012)
- acute neurological cerebellar toxicity (Shields et al., 2012)
- severe nausea, vomiting, and diarrhea (Rosenbaum et al., 2012)
- anxiety (Rosenbaum et al., 2012)
- confusion, agitation, stupor (Hofer et al., 2012)
- ataxia, mydriasis, and nystagmus (Hofer et al., 2012)
Remember, research chemicals like MXE are experimental chemicals that are not approved for human consumption. This is because not enough data exists currently about their effects in humans. Although some people are willing to ingest research chemicals, it is unreasonable to assume that they are safe to use recreationally.
- Methoxetamine associated reversible cerebellar toxicity: Three cases with analytical confirmation
- Here today, gone tomorrow… and back again? A review of herbal marijuana alternatives (K2, Spice), synthetic cathinones (bath salts), kratom, Salvia divinorum, methoxetamine, and piperazines
- Ketamine-like Effects After Recreational Use of Methoxetamine
- From “special K” to “special M”: the evolution of the recreational use of ketamine and methoxetamine
- Methoxetamine: From drug of abuse to rapid-acting antidepressant