Thursday, May 25, 2017
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NaphyroneNaphyrone is Schedule I in the United States. This means it is illegal to manufacture, possess, or distribute without a DEA license. Not available by prescription.

Addictive Potential: Unknown

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: Serotonin, dopamine, and norepinephrine reuptake inhibitor


Naphyrone is also known as naphthylpyrovalerone and  O-2482; it has been found in products named Energy-1 and NRG-1. Naphyrone is a napthyl analog of the cathinones, making it structurally related to mephedrone and MDPV. Naphyrone is typically administered orally or through nasal insufflation by recreational users. Although some users report positive psychostimulant effects, like mild euphoria and increased energy, users also report numerous negative effects (see a full list below).

Substance Identification:

     Mecke Reagent          Marquis Reagent     Liebermann’s Reagent   
Naphyrone  brown-orange green brown

(Info provided by Morris, 2013)

Side Effects & Adverse Reactions:

Naphyrone is a new substance, and little is known about its side effects, adverse reactions, long term damage, and/or addiction potential. According to Jebadurai (2013), some of the negative effects reported by recreational users include:

  • Tachycardia (>145/ minute) (on doses above 200mgs)
  • Cold blue fingers
  • Tingling sensation over extremities
  • Insomnia
  • Loss of appetite
  • Vascular color changes like blue, green, or purple hands, arms and knees
  • High blood pressure
  • Sweating
  • Increased body temperature
  • Jaw stiffness

Jebadurai (2013) also reported numerous psychopathological disturbances associated with naphyrone use. These include:

  • Paranoia
  • Visual hallucinations occurring for 48 hours
  • Disorganised thoughts
  • Intense anxiety
  • Depression
  • Obsessive symptoms
  • Poor concentration
  • Insomnia lasting for more than 5 days
  • Short term memory loss
  • Lack of motivation
  • Low self esteem

Remember, research chemicals are experimental chemicals that are not approved for human consumption. This is because very little, if any, empirical data exists regarding their effects in humans. Although some people are willing to ingest the research chemical Naphyrone, it is unreasonable to assume that it is in any way safe to use recreationally.


Qualitative research of online drug misuse communities with reference to the novel psychoactive substances

1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors

The naphyrone story: The Alpha or Beta‐naphthyl Isomer?

Sympathomimetic toxicity in a case of analytically confirmed recreational use of naphyrone(naphthylpyrovalerone)

Analyses of second‐generation ‘legal highs’ in the UK: Initial findings

High On The Designer Drug Naphyrone: A Case Report Of “Bath Salt” Toxicity

More Info:

Naphyrone Info Sheet by Crew 2000

Naphyrone Emergency Scheduled

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