Wednesday, March 29, 2017
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Pemoline

PemolinePemoline is Schedule IV in the United States.

Addictive Potential: Medium

Emergency Room Visits Yearly: Unknown

Mandatory Minumum Sentence: Not more than 3 years in prison

Mechanism of Action: Increases the Neurotransmitter Dopamine

Overview:

Pemoline is a CNS stimulant. Under the names Betanamin, Cylert, Tradon, and Ceractiv it was used as a medication to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy.

Pemoline is suspected of causing hepatotoxicity, so regular liver tests are performed on those treated with it. Since receiving FDA approval in 1975, it has been linked with 21 cases of liver failure, of which 13 resulted in liver replacement or death.

In 2005, the Food and Drug Administration (FDA) withdrew approval for pemoline due to pressure from several public advocacy groups. A more potent analogue of pemoline, 4-methylaminorex has appeared as a black market drug with abuse potential similar to methamphetamine.

In March 2005, Abbott Laboratories (Cylert® marketer) had discontinued the production of Cylert arguing economic reasons.

More Info:

Cylert FDA Warning

Full List of Childrens’ Psychiatric Medications

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