Saturday, March 25, 2017
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psilocybinPsilocybin is Schedule I in the United States. This means it is illegal to manufacture, buy, possess, or distribute without a DEA license. Not available by prescription. Fresh and dried psilocybin mushrooms are considered containers of Psilocybin, making them illegal to possess as well.

Addictive Potential: None

Emergency Room Visits Yearly: Unknown

Mandatory Minimum Sentence: Unknown

Mechanism of Action: agonist of the serotonin receptors primarily at 5-HT2A and 5-HT2C


Psilocybin is also known as 4-phosphoryloxy-N,N-dimethyltryptamine. It is a psychedelic tryptamine that is present in many species of mushrooms. This includes mushrooms in the genus Psilocybe, among others. Psilocybin-containing mushrooms are commonly called magic mushrooms or more simply “shrooms”.

Mushrooms containing psilocybin and psilocin are available fresh or dried and are typically taken orally. Interestingly, the potency of psilocybin-containing mushrooms is usually not reduced by heat (Erowid, 2009). Thus, psilocybin-containing mushrooms may also be brewed as a tea or added to other cooked foods to mask their bitter flavor. The hallucinogenic effects of psilocybin and psilocin appear within 20 minutes of ingestion and last for approximately 6 hours.


Psilocybin as an Adjunct to Addictions Treatment:

Trip Reports:

Side Effects and Adverse Reactions:

Psilocybin and psilocin can produce muscle relaxation or weakness, ataxia, excessive pupil dilation, nausea, stomach pain, vomiting, and drowsiness. Individuals who use psilocybin mushrooms also risk poisoning if one of the many existing varieties of poisonous mushrooms is incorrectly identified as a psilocybin mushroom. Beyond this, panic reactions and psychosis also may occur, particularly if a user ingests a large dose. Long-term effects such as Hallucinogen Persisting Perception Disorder (HPPD) have been described in case reports.

Frequency of Bad Trips. Cole (2014) examined the estimated frequency of bad trips associated with the use of psilocybin through an online survey of recreational users (n=2601); 1.4% of respondents reported experiencing bad trips during all of their psilocybin experiences, while 54.2% of respondents reported never having bad trips on psilocybin.




The NeuroSoup Trip Guide – This e-book discusses: Set, Setting, and Preparation for a Trip, Tips for Tripsitters, Aspects of the Entheogenic Experience, Working with Difficult Experiences, and Integration. Adverse psychological reactions, like flashbacks and HPPD, may potentially be avoided with proper preparation before and integration after entheogenic journeys. Thus, this e-book serves the purpose of harm reduction education. For clarity, NeuroSoup does not advocate the use of illegal, quasi-legal, or legal drugs. All substances that affect the central nervous system (legal or illegal) can have side effects, adverse reactions, and negative interactions with other drugs. Abstinence is always the best way to protect one’s health.

Recommended In-Print Books:

Other Informational Resources:

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