Overview:
Scopolamine, known by the names levo-duboisine and hyoscine, is a tropane alkaloid drug that has anticholinergic properties and muscarinic antagonist effects. It is obtained from plants such as belladonna, brugmansia, henbane, mandrake, and datura.
Scopolamine has legitimate medical applications in very minute doses. As an example, in the treatment of motion sickness, the dose, gradually released from a transdermal patch, is only 330 microgrammes (µg) per day.
Side Effects and Adverse Reactions:
The common side effects are related to the anticholinergic effect on parasympathetic postsynaptic receptors: dry mouth, throat and nasal passages in overdose cases progressing to impaired speech, thirst, blurred vision and sensitivity to light, constipation, difficulty urinating and tachycardia. Other effects of overdose include flushing and fever, as well as excitement, restlessness, hallucinations, or delirium. These side effects are commonly observed with oral or parenteral uses of the drug and generally not with topical ophthalmic use. An overdose can cause delirium, delusions, dangerous elevations of body temperature, stupor and death.
Research:
Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial
Muscarinic receptors: a novel therapeutic target for drug addiction
E-books:
The NeuroSoup Trip Guide - The free e-book version of The Neurosoup Trip Guide is now available online. It contains chapters on Choosing the Right Hallucinogen; Set, Setting, and Preparation for a Trip; Tips for Tripsitters; Aspects of the Entheogenic Experience; Working with Difficult Experiences; Integration; and References and Recommended Reading.
More Info:
Visit the New Community Trip Reports Area
How to Work With Bad Trips
