Overview:
Yohimbine, also known under the antiquated names quebrachin, aphrodin, corynine, yohimvetol, and hydroergotocin, is a natural amine or alkaloid, with central alpha-2 adrenergic antagonist activity, and clinically significant confirmed CNS effects in humans and other mammals, akin to those of psychostimulants but with a characteristic erogenic or "aphrodisiac" effects. The NIH states that yohimbine hydrochloride is the standardized form of yohimbine that is available as a prescription medicine in the United States, and has been shown in human studies to be effective in the treatment of male impotence.
Side Effects and Adverse Reactions:
Yohimbine has significant side effects, such as anxiety reactions. According to the Mayo Clinic, yohimbine can be dangerous if used in excessive amounts.
Higher doses of oral yohimbine may create numerous side effects, such as rapid heart rate, high blood pressure, overstimulation, insomnia and/or sleeplessness. Some effects in rare cases were panic attacks, hallucinations, headaches, dizziness, and skin flushing.
More serious adverse effects may include seizures and renal failure. Yohimbine should not be consumed by anyone with liver, kidney, heart disease, or a psychological disorder.
Consuming cheese, red wine, or liver while taking yohimbine is not recommended, as this may increase blood pressure to unsafe levels. The range between an effective dose and a dangerous dose is very narrow; too large of a dosage can be harmful and toxic. This may also lead to precipitation of panic disorder type reactions. In combination with NMDA receptor antagonists such as memantine, ketamine or DXM, yohimbine could theoretically induce or augment NMDA antagonists neurotoxicity, already demonstrated in rats.
Research:
Effects of Yohimbine in Healthy Subjects and Patients With Agoraphobia and Panic Disorder
Yohimbine for erectile dysfunction: a systematic review and meta-analysis
E-books:
The NeuroSoup Trip Guide - The free e-book version of The Neurosoup Trip Guide is now available online. It contains chapters on Choosing the Right Hallucinogen; Set, Setting, and Preparation for a Trip; Tips for Tripsitters; Aspects of the Entheogenic Experience; Working with Difficult Experiences; Integration; and References and Recommended Reading.
More Info:
Visit the New Community Trip Reports Area
How to Work With Bad Trips
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